VUF-6002

VUF-6002
Identifiers
IUPAC name
  • (6-chloro-1H-benzimidazol-2-yl)-(4-methylpiperazin-1-yl)methanone
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H15ClN4O
Molar mass278.74 g·mol−1
3D model (JSmol)
SMILES
  • CN3CCN(C(=O)c2nc1cc(Cl)ccc1[nH]2)CC3
InChI
  • InChI=1S/C13H15ClN4O/c1-17-4-6-18(7-5-17)13(19)12-15-10-3-2-9(14)8-11(10)16-12/h2-3,8H,4-7H2,1H3,(H,15,16) ☒N
  • Key:MOIWSUQWIOVGRH-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

VUF-6002 (JNJ-10191584) is a drug which acts as a potent and selective antagonist at the histamine H4 receptor.[1] It has anti-inflammatory and analgesic effects in animal studies of inflammatory diseases.[2]

See also

  • JNJ-7777120 (same molecule but where one nitrogen has been exchanged for a carbon)

References

  1. ^ Zhang M, Thurmond RL, Dunford PJ (March 2007). "The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders". Pharmacology & Therapeutics. 113 (3): 594–606. doi:10.1016/j.pharmthera.2006.11.008. PMID 17275092.
  2. ^ Coruzzi G, Adami M, Guaita E, de Esch IJ, Leurs R (June 2007). "Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation". European Journal of Pharmacology. 563 (1–3): 240–4. doi:10.1016/j.ejphar.2007.02.026. PMID 17382315.
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