Octamoxin
Skeletal formula of octamoxin
Names
Preferred IUPAC name
Systematic IUPAC name
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
UNII
InChI=1S/C8H20N2/c1-3-4-5-6-7-8(2)10-9/h8,10H,3-7,9H2,1-2H3
Y Key: FODQIVGFADUBKE-UHFFFAOYSA-N
Y
Properties
Chemical formula
C 8 H 20 N 2
Molar mass
144.262 g·mol−1
Density
0.831 g/mL
Boiling point
228 °C (442 °F; 501 K)
Pharmacology
Oral
Related compounds
Related compounds
Tuaminoheptane
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Octamoxin (trade names Ximaol , Nimaol ), also known as 2-octylhydrazine , is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant in the 1960s but is now no longer marketed.[ 2] [ 3] [ 4] [ 5]
See also
References
^ "Octamoxin - Compound Summary" . USA: National Center for Biotechnology Information. 26 March 2005. Identification and Related Records. Retrieved 31 May 2012 .
^ Ganellin CR, Triggle DJ (21 November 1996). Dictionary of pharmacological agents - Google Books . CRC Press. ISBN 9780412466304 .
^ "13-06781. Octamoxin [Archived]: The Merck Index" .
^ Levy J, Michel-Ber E (1966). "[Relations between the antidepressive effects of octamoxine revealed by 3 pharmacological tests and inhibition of cerebral monoamine oxidase in mice]". Thérapie (in French). 21 (4): 929– 45. PMID 5925088 .
^ Gayral L, Stern H, Puyuelo R (1966). "[Indications and results of the treatment of mental depression by octamoxine (ximaol)]". Thérapie (in French). 21 (5): 1183– 90. PMID 5976767 .
SSRIs Tooltip Selective serotonin reuptake inhibitors SNRIs Tooltip Serotonin–norepinephrine reuptake inhibitors NRIs Tooltip Norepinephrine reuptake inhibitors NDRIs Tooltip Norepinephrine–dopamine reuptake inhibitors NaSSAs Tooltip Noradrenergic and specific serotonergic antidepressants SARIs Tooltip Serotonin antagonist and reuptake inhibitors SMS Tooltip Serotonin modulator and stimulators Others
TCAs Tooltip Tricyclic antidepressants TeCAs Tooltip Tetracyclic antidepressants Others
Non-selective MAOA Tooltip Monoamine oxidase A -selectiveMAOB Tooltip Monoamine oxidase B -selective
Non-specific
AAAD Tooltip Aromatic L-amino acid decarboxylase MAO Tooltip Monoamine oxidase
Phenethylamines (dopamine , epinephrine ,norepinephrine )
PAH Tooltip Phenylalanine hydroxylase
Substrates→Products: Phenylalanine→Tyrosine
TH Tooltip Tyrosine hydroxylase DBH Tooltip Dopamine beta-hydroxylase PNMT Tooltip Phenylethanolamine N-methyltransferase
Inhibitors: CGS-19281A
SKF-64139
SKF-7698
COMT Tooltip Catechol-O-methyl transferase
Tryptamines (serotonin , melatonin )
TPH Tooltip Tryptophan hydroxylase
Substrates→Products: Tryptophan→5-HTP
AANAT Tooltip Serotonin N-acetyl transferase ASMT Tooltip Acetylserotonin O-methyltransferase
Histamine
HDC Tooltip Histidine decarboxylase
Substrates→Products: L -Histidine→Histamine
HNMT Tooltip Histamine N-methyltransferase
Substrates→Products: Histamine→N-Methylhistamine
DAO Tooltip Diamine oxidase
Substrates→Products: Histamine→Imidazole acetic acid
See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine neurotoxins