If you're looking for (e.g.) a h2 tag nested within a td tag where there's only whitespace in between the two, just use \s which includes spaces, newlines, etc. eg::
preg_match('#<td>\s*<h2>(.*?)</h2>\s*</td>#i',$str,$matches);
// result is in $matches[1]
See it in action here.
For your interest, here is a list of different modifiers you can pass in to preg_* functions. Flags that may interest you are:
s ("dotall") : this one makes . match every character, including newlines. So, say your <h2>.....</h2> was spread over multiple lines. Then you'd have to do
preg_match('#<td>\s*<h2>(.*?)</h2>\s*</td>#is',$str,$matches);
in order to have the .* go over multiple lines (see the extra s at the end of the regex?).
m ("multiline") : this one just lets ^ and $ match start/end of line instead of just the start/end of string. You only really need it if you're using ^ and $ in your pattern and want them to match the start/end of each individual line in your input.