I have the below query to be re-written without using the IsNull operator as I am using the encryption on those columns and IsNull isn't supported
I suppose you mean that columns c.email1 and E.email are never null, but they sometimes contain encrypted strings that convey the absence of data in a manner similar to that ordinarily conveyed by a NULL. For example, maybe the encrypted form of an empty string is used. In that event, you can compare their values to the encrypted null-equivalent:
Case
When Indicator = 'N' Then Null
when c.email1 != 'some-encrypted-string-equivalent-to-null' then c.email1
when E.email != 'some-encrypted-string-equivalent-to-null' then E.email
else ORG_Email
End EmailAddress
Of course, that assumes that there is a single null-equivalent string, at least on a per-column basis, which might not be the case. If it isn't then the only options I see are
decrypt the e-mail values in the query (possibly via a user-defined function) and write the conditions based on the decrypted values, or
return both the encypted c.email1 and E.email as separate columns, or null for both if Indicator is 'N', and select which one to use on the application side, after decryption.