Depends on whether you want the final, mutated value of x to be passed back to the caller of the function or mutate it only locally.
For local-only mutation, just declare another variable, which would be mutable, but initially will have the value of x:
let f x =
let mutable i = x
while i>0 do
printfn "%d" i
i <- i-1
For passing the result back to the caller, you can use a ref-cell:
let f (x: int ref) =
while x.Value>0 do
printfn "%d" x.Value
x := x.Value - 1
Note that now you have to refer to the ref-cell contents via the .Value property (or you can instead use operator !, as in x := !x - 1), and the mutation is now done via :=. Plus, the consumer of such function now has to create a ref-cell before passing it in:
let x = ref 5
f x
printfn "%d" x.Value // prints "0"
Having said that, I must point out that mutation is generally less reliable, more error-prone than pure values. The normal way to write "loops" in pure functional programming is via recursion:
let rec f x =
if x > 0 then
printf "%d" x
f (x-1)
Here, each call to f makes another call to f with the value of x decreased by 1. This will have the same effect as the loop, but now there is no mutation, which means easier debugging and testing.